The purification team is highly experienced in process development for cGMP manufacturing of recombinant proteins and monoclonal antibodies. Rapid development of an efficient process for clinical production and further optimization for commercial production are primary goals.
An Äkta Pilot and a number of Äkta Explorers are available for rapidly screening and executing different column conditions.
Columns with diameters up to 5 cm are available to develop process steps. In addition, the team focuses on developing high-yield, robust processes, and the associated analytics necessary for process development and monitoring.
Close interactions with other development teams ensure success during transfer and commercial cGMP production.
- Process development and scale-up
- Process justification and validation
- Chromatography technology
- high and low pressure systems - Custom design of chromatographic media
- Protein crystallization
- Protein modification through chemical and enzymatic conversion
- Processing of low solubility proteins
- Innovative recovery processes
- Continuous membrane systems